From off-Cape Cod and west of Hyannis:
Take Route 6 (the Mid-Cape Highway) east to Exit 6. From the off-ramp, turn right onto Route 132, and follow it until you reach the light at Attucks Lane. Turn left and follow the signs to the airport..

From the Lower/Outer Cape, east of Hyannis:
Take Route 6 (the Mid-Cape Highway) west to Exit 7. From the off-ramp, turn left onto Willow Street/Yarmouth Road and go to the intersection with Route 28. Turn right onto Route 28, and follow it to the new airport entrance ramp on the right, just before Airport Rotary. 

From the Mashpee/Falmouth area:
Take Route 28 through Cotuit, Marstons Mills, Osterville and Centerville into Hyannis. Go three quarters of the war around the Airport Rotary, taking Route 132 away from Hyannis. Watch for Hinckley Road soon after exiting the rotary, and turn right there. The airport will be ahead of you.